MABS1214

Anti-PEG (methoxy group) Antibody, clone RM105

clone RM105, from rabbit, purified by affinity chromatography

• 동의어(들): PEG, pegylation, methoxy group, Polyethylene glycol, polyethylene oxide, PEO, polyoxyethylene, POE
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: RM105, monoclonal
• 정제법: affinity chromatography
• 종 반응성(상동성에 의해 예측): all
• 기술: ELISA: suitable; immunohistochemistry: suitable; western blot: suitable
• 동형: IgG
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified

설명

일반 설명

Polyethylene glycol (PEG) is a polyether compound with many applications from industrial manufacturing to medicine. PEG is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight. PEG is a family of long chain polymers attached to a glycerine backbone. Some of the properties of PEG are nonionic, nontoxic, biocompatible, strongly hydrophilic polymer, which has a large exclusion volume in aqueous solution. PEGylation is the act of covalently coupling a PEG structure to another larger molecule, for example, a therapeutic protein, which is then referred to as a PEGylated protein. The covalent attachment of PEG (PEGylation) is commonly used to modify a variety of proteins and drugs. Some of the therapeutical benefits of PEGylated molecules include increased bioavailability, increased blood circulation of the drug, optimized pharmacokinetics, decreased immunogenicity, and decreased frequency of administration. Additional benefits of PEGylated molecules include decelerated renal excretion, improved stability towards proteolysis, increased solubility of the biopharmaceutical in aqueous solutions, increased hydrodynamic radius, reduced immunogenicity and proteolytic cleavage. This antibody reacts to the terminal methoxy group of Polyethylene glycol.

면역원

recombinant protein corresponding to All PEG (methoxy group).

애플리케이션

Anti-PEG (methoxy group), clone RM105 is an antibody against PEG (methoxy group) for use in WB, IH, ELISA.

Immunohistochemistry Analysis: 0.5 μg/mL of this antibody detected PEG (methoxy)-BSA in injected mouse liver and kidney
ELISA Analysis: Multiple concentrations of this antibody was used to detect three different BSA-PEG conjugates (5K, 40K and 40K branched)

Research Category
Signaling

Research Sub Category
Epitope Tags

품질

Evaluated by Western Blotting on recombinant methoxyPEG conjugated BSA

Western Blotting Analysis: A 1:1;000 dilution of this antibody detected PEG (methoxy group) on conjugated recombinant BSA

표적 설명

BSA is 66 kD, methoxyPEG is 5 kD. Additional bands above 66 kD is due to different levels of conjugation and dimerization.

물리적 형태

Protein A purified

Purified rabbit monoclonal IgG in PBS buffer containing 1% BSA and 0.09% sodium azide

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable