MABN774

Anti-TDP-43 Antibody, clone DB9

clone DB9, from mouse

• 동의어(들): TAR DNA-binding protein 43, TDP-43, TDP43, TAR DNA binding protein-43
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: DB9, monoclonal
• 종 반응성: human
• 기술: immunohistochemistry: suitable; western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_031401
• UniProt 수납 번호: Q13148
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... TARDBP(23435)

설명

일반 설명

TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson′s disease and Alzheimer′s disease.

면역원

The antibody was raised against an immunogen consisting of His-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.

애플리케이션

Detect TDP-43 using this Anti-TDP-43 Antibody, clone DB9 validated for use in western blotting & IHC.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TDP-43 in human cerebellum, pancreas, and thalamus tissues.

품질

Evaluated by Western Blotting in SH-SY-5Y cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected TDP-43 in 10 µg of SH-SY-5Y cell lysate.

표적 설명

~43 kDa observed

물리적 형태

Format: Purified

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable