MABN50

Anti-Olig2 Antibody, clone 211F1.1

clone 211F1.1, from mouse

• 동의어(들): oligodendrocyte lineage transcription factor 2, oligodendrocyte-specific bHLH transcription factor 2, human protein kinase C-binding protein RACK17, Protein kinase C-binding protein 2, protein kinase C binding protein 2, Class B basic helix-loop-helix pr
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 클론: 211F1.1, monoclonal
• 종 반응성: mouse
• 종 반응성(상동성에 의해 예측): rat (based on 100% sequence homology), human (based on 100% sequence homology)
• 기술: immunocytochemistry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• 동형: IgG2aκ
• NCBI 수납 번호: NP_005797
• UniProt 수납 번호: Q13516
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... OLIG2(10215)

설명

일반 설명

Oligodendrocyte lineage transcription factor 2 (Olig2) is a protein belonging to group A of the OLIG family of basic helix-loop-helix transcription factors (bHLH). bHLH proteins are divided into 6 groups (A-F), and characterized by their biochemical properties and structure. Olig2 is classified as group A due to its ability to form heterodimers with other bHLH proteins and binding to the E box. Olig2 has a crucial role during development in specifying the final location of motor neurons and oligodendrocytes in the spinal cord, along with the development within the hindbrain of somatic motor neurons. Olig2 expression is observed within oligodendrocytes and in developing astrocytes. Recent studies have shown strong expression of Olig2 in human oligodendrogliomas, primary tumors within the central nervous system, and moderate expression in astrocytomas. These observations have led to the proposal of Olig2 having potential as an oligodendroglioma diagnostic marker.

특이성

Anti-Olig2 Antibody recognizes Olig2.

면역원

Epitope: Unknown

Recombinant protein corresponding to human Olig2.

애플리케이션

Detect Olig2 using this Anti-Olig2 Antibody, clone 211F1.1 validated for use in WB, IC, IH & IP.

Immunohistochemistry Analysis: This antibody has been shown to detect Olig2 in coronal brain tissue as reported by an independent laboratory (Cai, J., et al. (2007). Development. 134:1887-1899).

Immunocytochemistry Analysis: This antibody has been shown to detect Olig2, as reported by an independent laboratory (Lee, S.K., et al. (1995). Genes & Dev. 19:282-294).

Immunoprecipitation Analysis: This antibody has been shown to detect Olig2, as reported by an independent laboratory (Lee, S.K., et al. (1995). Genes & Dev. 19:282-294).

Research Category
Neuroscience

Research Sub Category
Neuronal & Glial Markers

품질

Evaluated by Western Blot in mouse brain lysate.

Western Blot Analysis: 2 µg/mL of this antibody detected Olig2 on 10 µg of mouse brain lysate.

표적 설명

~37 kDa observed

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Mouse brain lysate

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable