MABN476

Anti-Paris/ZNF746 Antibody, clone N196/16

clone N196/16, from mouse

• 동의어(들): Zinc finger protein 746, Parkin-interacting substrate, PARIS
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: N196/16, monoclonal
• 종 반응성: mouse, human, rat
• 기술: western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_001156946
• UniProt 수납 번호: Q6NUN9
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ZNF746(155061)

설명

일반 설명

Zinc finger protein 746 (ZNF746) is also called Parkin-interacting substrate (PARIS). ZNF746 is a repressor of transcription that binds to promoters and represses the transcription of PGC-1-alpha (PPARGC1A), making it important to the regulation of neuron death. ZNF746 may also contribute to neurodegeneration in Parkinson disease.

특이성

This antibody recognizes the N-terminus of ZNF746. This antibody does not cross react with ZNF783 or ZNF398 (Prof. J. Trimmer, University of California, Davis.).

면역원

Epitope: N-terminus

Recombinant protein corresponding to the N-terminus of human Paris/ZNF746.

애플리케이션

Anti-Paris/ZNF746 Antibody, clone N196/16 is a highly specific mouse monoclonal antibody & that targets Zinc Finger Protein & has been tested in western blotting.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Western Blotting Analysis: 1 µg/mL of this antibody detected Paris/ZNF746 in 10 µg of RAW264.7 cell lysate. Immunohistochemistry Analysis: A representative lot detected Paris/ZNF746 in rat brain tissue (Prof. J. Trimmer, University of California, Davis.).

품질

Evaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected Paris/ZNF746 in 10 µg of HEK293 cell lysate.

표적 설명

~72 kDa observed. Uniprot describes 3 isoforms, two at 69 kDa and one at 49 kDa This protein is ubiquitinated and has been observed at higher molecular weights (Shin, J. H., et al. (2011). Cell. 144(5):689-702.).

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
HEK293 cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable