MABN453

Anti-CHRDL1 Antibody, clone 10C9.3

clone 10C9.3, from mouse

• 동의어(들): Chordin-like protein 1, Neuralin-1, Neurogenesin-1, Ventroptin
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 클론: 10C9.3, monoclonal
• application: IHC; WB
• 종 반응성: human, rat
• 기술: immunohistochemistry: suitable; western blot: suitable

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 10C9.3, monoclonal
• 종 반응성: human, rat
• 기술: immunohistochemistry: suitable; western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_001137453
• UniProt 수납 번호: Q9BU40
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CHRDL1(91851)

설명

일반 설명

Chordin-like protein 1 (CHRDL1) is an important secreted developmental mediator protein expressed in developing cornea, retina, brain, cerebellum and neocortex and developing bone. CHRDL1 in the nervous system alters the fate commitment of neural stem cells from gliogenesis to neurogenesis and contributes to neuronal differentiation of neural stem cells in the brain by the preventing the adoption of a glial fate. CHRDL1 also plays a critical role in dorsventral axis formation and regulates the action of BMP4 and preventing it from interacting with its receptors. In the developing eye CHRDL1 regulates retinal angiogenesis and the development of the anterior segment of the eye. Mutations in CHRDL1 are associated with various eye disorders and in particular one named Megalocornea 1, an X-linked developmental disease.

면역원

KLH-conjugated linear peptide corresponding to human CHRDL1.

애플리케이션

Research Category
Neuroscience

This Anti-CHRDL1 Antibody, clone 10C9.3 is validated for use in Western Blotting and Immunohistochemistry for the detection of CHRDL1.

품질

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected CHRDL1 in 200 µg of rat brain tissue lysate.

표적 설명

~65 kDa observed. The calculated molecular weight of this protein is 50 kDa, but can be observed at ~65 kDa due to high glycosylation.

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected CHRDL1 in 200 µg of human brain tissue lysate.
Immunohistochemistry Analysis: A 1:50-1,000 dilution from a representative lot detected CHRDL1 in human retina, human cerebellum, rat cerebellum, and rat cerebral cortex tissue.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable