MABN263

Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8

clone 10F10-C1-B8, from mouse

• 동의어(들): Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 10F10-C1-B8, monoclonal
• 종 반응성: rat
• 기술: immunocytochemistry: suitable; western blot: suitable
• 동형: IgG2bκ
• NCBI 수납 번호: NP_899156
• UniProt 수납 번호: P18508
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: rat ... Gabrg2(29709)

설명

일반 설명

GABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.

면역원

Linear peptide corresponding to rat GABA(A) receptor subunit gamma-2.

애플리케이션

Detect GABA(A) receptor subunit gamma-2 using this Anti-GABA(A) receptor subunit gamma-2 Antibody, clone 10F10-C1-B8 validated for use in Western Blotting, ICC.

Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected GABA(A) receptor subunit gamma-2 in rat hippocampal neurons. Image courtesy from the laboratory of Dr. Jaideep Kapur, University of Virginia.

품질

Evaluated by Western Blot in PC-12 cell lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 in 10 µg of PC-12 cell lysate.

표적 설명

~54 kDa observed

물리적 형태

Format: Purified

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable