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Merck
모든 사진(1)

주요 문서

MABN2490

Sigma-Aldrich

Anti-mutant HTT Antibody, clone PHP1

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

항체 형태

purified antibody

클론

PHP1
monoclonal

정제법

using protein G

종 반응성

mouse, human, mouse

농도

(Please refer to lot specific datasheet.)

기술

dot blot: suitable
electron microscopy: suitable
immunohistochemistry: suitable
western blot: suitable

동형

IgG1κ

UniProt 수납 번호

동작 모드

| inhibits

일반 설명

GST-tagged recombinant exon1 of wild-type human huntingtin HTTx1 (20Q) protein.

특이성

Clone PHP1 is mouse monoclonal antibody that detects mutated Huntingtin protein. It targets an epitope QAQPLLPQP within the proline-rich domain.

애플리케이션

Western Blotting Analysis: A representative lot detected mutant HTT in Western Blotting applications (Ko, J., et. al. (2018). Hum Mol Genet. 27(13):2330-2343).

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected mutant HTT in brain tissue lysates of 6 and 9 month-old WT or Q140 KI HD mice (Courtesy of Ali Khoshnan, Ph.D., California Institute of Technology, Paadena, CA).

Electron Microscopy Analysis: A representative lot detected mutant HTT in Immuno-Electron Microscopy applications (Ko, J., et. al. (2018). Hum. Mol. Genet. 27(13): 2330-2343).

Inhibits Activity/Function Analysis: A representative lot blocked seeding and subsequent fibril assembly of mHTTx1 in vitro and in a cell culture model of HD. (Ko, J., et. al. (2018). Hum Mol Genet. 27(13):2330-2343).

Immunohistochemistry Analysis: A representative lot detected mutant HTT in Immunohistochemistry applications (Ko, J., et. al. (2018). Hum Mol Genet. 27(13): 2330-2343).

Dot Blot Analysis: A representative lot detected mutant HTT in Dot Blot applications (Ko, J., et. al. (2018). Hum Mol Genet. 27(13):2330-2343).

품질

Evaluated by Immunohistochemistry (Paraffin) in Human Huntington′s diseased brain tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected mutant HTT in Human Huntington′s diseased brain tissue sections.

물리적 특성

347.60 kDa calculated.

물리적 형태

Purified mouse monoclonal antibody IgG1 in PBS without azide.

저장 및 안정성

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

기타 정보

Human, Mouse.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

시험 성적서(COA)

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