MABN224

Anti-Thorase Antibody, clone 9G7.1

clone 9G7.1, from mouse

• 동의어(들): ATPase family AAA domain-containing protein 1, Thorase
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 9G7.1, monoclonal
• 종 반응성: human
• 종 반응성(상동성에 의해 예측): mouse (based on 100% sequence homology)
• 기술: western blot: suitable
• 동형: IgG2bκ
• NCBI 수납 번호: NP_116199
• UniProt 수납 번호: Q8NBU5
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ATAD1(84896)

설명

일반 설명

Thorase is an ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Thorase thus helps mediate synaptic plasticity and learning and memory. Thorase expression is required for NMDA-stimulated AMPAR internalization and for the inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane as both of these require ATP processing by Thorase. Thorase is vital for keeping in balance the molecular construction-deconstruction cycle that is required for memory formation. Thorase is one of many AAA+ ATPases that drive the assembly of proteins needed to form specialized receptors at the surfaces of synapses. These receptors are stimulated by neighboring neurons, setting up the signaling and answering connections vital to brain function. Thorase regulates the all-important complementary process of receptor disassembly at synapses, which ultimately tamps down signaling. Thorase is a postsynaptic localized protein, and also is associated with the peroxisome and cell junctions and synapses. Thorase is expressed in the brain and testis primarily.

면역원

GST-tagged recombinant protein corresponding to human Thorase.

애플리케이션

This Anti-Thorase Antibody, clone 9G7.1 is validated for use in Western Blotting for the detection of Thorase.

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Thorase in 10 µg of human brain tissue lysate.

품질

Evaluated by Western Blotting in human lymph node tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Thorase in 10 µg of human lymph node tissue lysate.

표적 설명

~41 kDa observed

물리적 형태

Format: Purified

기타 정보

Concentration: Please refer to lot specific datasheet.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable