MABE988

Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1

clone 7D9.1, from mouse

• 동의어(들): Homeobox protein CDX-2, Homeobox protein CDX-2, CDX-3, Caudal-type homeobox protein 2
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.43

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 7D9.1, monoclonal
• 종 반응성: human
• 기술: immunohistochemistry: suitable (paraffin); western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_001256
• UniProt 수납 번호: Q99626
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CDX2(1045)

설명

일반 설명

Homeobox protein CDX-2 (UniProt Q99626; also known as Caudal-type homeobox protein 2, Caudal type homeobox transcription factor 2, CDX-3) is encoded by the CDX2 (also known as CDX3, CDX2/AS) gene (Gene ID 1045) in human. CDX-2 is a transcription factor that plays an important role during embryonic development, where it determines intestinal identity in the presumptive gut endoderm. CDX-2 is also required for maintenance of intestinal identity in the intestinal epithelium throughout adulthood. Mitogen-activated protein kinases (MAPK) are reported to modulate CDX2 transcriptional activity and half-life via phosphorylation. Reduction of CDX2 expression facilitates tumor progression in murine models of colorectal cancer (CRC) and decreased CDX2 expression level in CRC correlates with poor prognosis in human.

면역원

Epitope: Internal

GST-tagged recombinant protein corresponding to human Homeobox protein CDX-2.

애플리케이션

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Homeobox protein CDX-2 in human colon and human colorectal cancer tissue.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Nuclear Receptors

This Anti-Homeobox protein CDX-2 Antibody, clone 7D9.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of Homeobox protein CDX-2.

품질

Evaluated by Western Blotting in human colorectal adenocarcinoma DLD-1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Homeobox protein CDX-2 in 10 µg of human colorectal adenocarcinoma DLD-1 cell lysate.

표적 설명

~35/39 kDa observed. Target band often appears as a doublet due to posttranslational modifications (phosphorylations & polyubiquitinations).

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable