MABE889

Anti-ADAR2 Antibody, clone 1.3.1

clone 1.3.1, from mouse

• 동의어(들): Double-stranded RNA-specific editase 1, RNA-editing deaminase 1, RNA-editing enzyme 1, dsRNA adenosine deaminase
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 1.3.1, monoclonal
• 종 반응성: human
• 기술: western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_001103
• UniProt 수납 번호: P78563
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ADARB1(104)

설명

일반 설명

Double-stranded RNA-specific editase 1, or RNA-editing deaminase 1, or RNA-editing enzyme 1, or dsRNA adensine deaminase, and encoded by the human gene ADARB1/ ADAR2, DRADA2, RED1 is an enzyme that catalyzes the deamination of adenosine in dsRNA to inosine in a step called A to I RNA editing. This editing alters gene expression by changing codon usage and splicing sites as well as altering general RNA stability. So far the enzyme has been shown to edit and destabilize cancer associated genes as well as functional neurotransmitter receptors, and channel proteins. Interestingly, its activity appears to inhibit cell proliferation and migration in some cells and promote exocytosis and metabolism in others, likely to do differential affects on particular important mRNAs. Highly expressed in brain, heart with lower expression in lung, kidney and liver tissues. Interestingly RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen.

면역원

Epitope: C-terminus

GST-tagged recombinant protein corresponding to the C-terminus of human ADAR2.

애플리케이션

Anti-ADAR2 Antibody, clone 1.3.1 detects level of ADAR2 & has been published & validated for use in ADAR2.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Chromatin Biology

품질

Evaluated by Western Blotting in HeLa nuclear extract.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected ADAR2 in 10 µg of HeLa nuclear extract.

표적 설명

~80 kDa observed

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable