추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
6E5, monoclonal
종 반응성
human
농도
1 mg/mL
기술
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
동형
IgG2aκ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... ZEB2(9839)
일반 설명
Smad-interacting protein 1 (SIP1, SMADIP1), also known as Zinc finger E-box-binding homeobox 2 (ZEB2), and Zinc finger homeobox protein 1b (ZFHX1B, ZFX1B), is a transcriptional inhibitor that binds to DNA sequence 5′-CACCT-3′ in different promoters and interacts with activated SMADs. ZEB2 has been shown to repress the transcription of the E-cadherin gene and induce epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing in vitro. It is suggested that ZEB2 contributes to tumor progression since it’s been demonstrated to protect cells from DNA damage-induced apoptosis. Recent studies have shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, implying that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Mowat-Wilson syndrome (MWIS), also known as Hirschsprung disease-mental syndrome.
면역원
Epitope: N-terminus
His-tagged recombinant protein corresponding to the N-terminus of Human SIP1.
애플리케이션
Anti-SIP1 Antibody, clone 6E5 is an antibody against SIP1 for use in western blotting, ICC & IHC.
Research Category
Stem Cell Research
Stem Cell Research
Research Sub Category
Pluripotent & Early Differentiation
Pluripotent & Early Differentiation
This antibody has been shown to work in Immunocytochemistry and Immunohistochemistry applications (Oztas et al., 2010).
품질
Evaluated by Western Blot in a SK-Hep1 cell lysate. 2ug/ml (1:500 dilution) of this antibody detected SIP-1 in a SK-Hep1 cell lysate.
표적 설명
~220 kDa observed
물리적 형태
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG2aκ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer.
Sayan, AE; Griffiths, TR; Pal, R; Browne, GJ; Ruddick, A; Yagci, T; Edwards, R; Mayer et al.
Proceedings of the National Academy of Sciences of the USA null
Emin Oztas et al.
Experimental and molecular pathology, 89(2), 182-189 (2010-06-03)
Smad-interacting protein 1 (SIP1, also known as ZEB2) represses the transcription of E-cadherin and mediates epithelial-mesenchymal transition in development and tumor metastasis. Due to the lack of human SIP1-specific antibodies, its expression in human tumor tissues has not been studied
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