MABC557

Anti-FANCA Antibody, clone 5G9

clone 5G9, from mouse

• 동의어(들): Fanconi anemia group A protein, Protein FACA
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 5G9, monoclonal
• 종 반응성: human
• 기술: immunoprecipitation (IP): suitable; western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_000126
• UniProt 수납 번호: O15360
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... FANCA(2175)

설명

일반 설명

FANCA, also named as FAA, FACA and FANCH, belongs to the multisubunit FA complex which is not found in patients with Fanconi anemia. FANCA may be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Mutations in FANCA have been associated with Fanconi anemia (FA) which is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies.

면역원

KLH-conjugated linear peptide corresponding to the C-terminus of human FANCA.

애플리케이션

Anti-FANCA Antibody, clone 5G9 is a highly specific mouse monoclonal antibody, that targets FANCA & has been tested in western blotting & IP.

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected FANCA in 10 µg of HeLa cell lysate.

Western Blotting Analysis: A representative lot from an independent laboratory detected FANCA in normal HSC93 and FA mutant lymphoblast whole cell extracts. The same lot also detected FANCA in HeLa whole cell extracts and in FANCA transfected PD430 whole cell extracts (Tremblay, C. S., et al. (2008). Blood. 112(5):2062-2070.).

Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated FANCA from yeast extracts expressing FANCA. The same lot also immunoprecipiated FANCA from 293T whole cell extracts expressing FANCA (Tremblay, C. S., et al. (2008). Blood. 112(5):2062-2070.)

Immunoprecipitation Analysis: A representative lot from an independent laboratory immunoprecipitated FANCA from FANCA wild type FA lymphoblast cell lysate (de Winter, J. P., et al. (2000). Hum Mol Genet. 9(18):2665-2674.).

품질

Evaluated by Western Blotting in Raji cell lysates.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FANCA in 10 µg of Raji cell lysate.

표적 설명

~165 kDa observed

물리적 형태

Format: Purified

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable