MABC521

Anti-XBP1s Antibody, clone 143F (active form)

clone 143F, from mouse

• 동의어(들): X-box-binding protein 1, XBP-1, Tax-responsive element-binding protein 5
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 143F, monoclonal
• 종 반응성: human
• 기술: immunohistochemistry: suitable; western blot: suitable
• 동형: IgG2aκ
• NCBI 수납 번호: NP_001073007
• UniProt 수납 번호: P17861
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... XBP1(7494)

설명

일반 설명

XBP-1, also known as X-box-binding protein 1 or Tax-responsive element-binding protein 5, and encoded by the gene XBP1/TREB5/XBP2, is a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP-1 also acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). XBP-1 binds DNA preferentially at CRE-like elements but also to some TPA response elements (TRE). XBP-1 is expressed in the nucleus. Defects in XBP-1 may be associated with Major affective disorder 7 (MAFD7) a major psychiatric disorder that is characterized by severe mood swings, with fluctuation between two abnormal mood states (manic or major depressive episode). Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy.

면역원

Epitope: C-terminus

GST-tagged recombinant protein corresponding to the C-terminus of human XBP-1S, clone 143F (active form).

애플리케이션

Anti-XBP1s Antibody, clone 143F (active form) is an antibody against XBP1s for use in IHC & western blotting.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Western Blotting Analyis: A representative lot from an independent laboratory detected XBP-1S, clone 143F (active form) in SK-MM-2, KARPAS 620, NCI-H929, and LP-1 cell lysates (Maestre, L., et al. (2009). Haematologica. 94(3):419-422.).

Immunohistochemistry Analysis: A representative lot from an independent laboratory detected XBP-1S, clone 143F (active form) in human tonsil and lymphoplasmacytic cells (Maestre, L., et al. (2009). Haematologica. 94(3):419-422.).

품질

Evaluated by Immunohistochemistry in human skin tissues.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected XBP-1S, clone 143F (active form) in human skin tissues.

표적 설명

29 kDa calculated

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable