추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
8211, monoclonal
종 반응성
human
제조업체/상표
Chemicon®
기술
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
동형
IgG1
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... NTF3(4908)
일반 설명
The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity. p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations. The p75 receptor binds nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4 with varying specificities. The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death. It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells.
특이성
Reacts with NGF-receptors in human system.
면역원
Membrane fragments of the melanoma cell line WM-9 (Herlyn et al., 1983).
애플리케이션
Anti-Nerve Growth Factor Receptor (p75) Antibody, clone 8211 is an antibody against Nerve Growth Factor Receptor (p75) for use in IC, IH, IH(P) & WB.
Immunohistochemistry: 5-10 μg/mL
Immunocytochemistry: 5-10 μg/mL
Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf
Western Blot: 1ug/mL
Immunoabsorptive purification of NGF-receptors
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 5-10 μg/mL
Immunohistochemistry on paraffin sections: Cattoretti, Blood 81:1726-1738, 1993. http://www.bloodjournal.org/cgi/reprint/81/7/1726.pdf
Western Blot: 1ug/mL
Immunoabsorptive purification of NGF-receptors
Optimal working dilutions must be determined by end user.
표적 설명
75 kDa
결합
Replaces: 04-1111
물리적 형태
Format: Purified
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Nerve growth factor receptor immunohistochemistry has a limited additional value to diagnose Hirschsprung\'s disease.
Granstrom AL, Orrego A, Svensson PJ, Almstrom M, Skikuniene J, Wester T
Pediatric Surgery International null
Production and characterization of monoclonal antibodies against human malignant melanoma.
Herlyn, M, et al.
Cancer Investigation, 1, 215-224 (1983)
Nerve growth factor is mitogenic for cancerous but not normal human breast epithelial cells.
Descamps, S, et al.
The Journal of Biological Chemistry, 273, 16659-16662 (1998)
F Hefti et al.
Annals of neurology, 20(3), 275-281 (1986-09-01)
Alzheimer's disease is associated with a pronounced loss of the cholinergic neurons that form the ascending cholinergic projections of the basal forebrain. Even though the disease is also characterized by changes in other neuronal systems and by a high frequency
Darren Carwardine et al.
PloS one, 12(12), e0188967-e0188967 (2017-12-12)
Olfactory ensheathing cell (OEC) transplantation is a promising strategy for treating spinal cord injury (SCI), as has been demonstrated in experimental SCI models and naturally occurring SCI in dogs. However, the presence of chondroitin sulphate proteoglycans within the extracellular matrix
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