추천 제품
생물학적 소스
rat
Quality Level
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
6C7.1, monoclonal
종 반응성
mouse
기술
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
동형
IgG1κ
NCBI 수납 번호
UniProt 수납 번호
배송 상태
dry ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... L1CAM(3897) , VCAM1(7412)
일반 설명
Vascular cell adhesion protein 1 (VCAM-1) is a cell surface adhesion molecule belonging to the immunoglobulin cell-cell adhesion receptor family and is comprised of seven Ig-like C2-type domains. VCAM-1 is a crucial component in cell-cell recognition and seems to be involved in cellular adhesion between endothelial cells and leukocytes. It has a regulatory role for both signal transduction and adhesion through its interaction with leukocyte beta-1 integrin VLA4, an interaction that is potentially involved in immune and inflammatory emigration responses of leukocytes. Studies have shown upregulation of VCAM-1 to be critical in responding to inflammatory diseases such as atherosclerosis. VCAM-1 is primarily expressed in endothelial cells and is expressed as two known isoforms found within the cell membrane. Isoform 1 functions as a single-pass type 1 membrane protein, while Isoform 2 acts as a GPI-anchor.
면역원
Mouse endothelial cells
애플리케이션
Anti-VCAM-1 (CD106) Antibody, clone 6C7.1 is an antibody against VCAM-1 (CD106) for use in FC, IP, IC, IH.
Immunohistochemistry Analysis: A previous lot was used by independent laboratory in IH. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)
Immunocytochemistry Analysis: A previous lot was used by independent laboratory in IC. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)
Immunocytochemistry Analysis: A previous lot was used by independent laboratory in IC. (Norman, U., et al. (2008). Journal of Leukocyte Biology. 84:68-76.)
품질
Evaluated by Flow Cytometry in mouse bone marrow cells.
Flow Cytometry Analysis: 10 µg of this antibody detected VCAM-1 on mouse bone marrow cells.
Flow Cytometry Analysis: 10 µg of this antibody detected VCAM-1 on mouse bone marrow cells.
표적 설명
81 kDa calculated
물리적 형태
Format: Purified
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
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