MAB2609

Anti-beta Arrestin 1 Antibody, clone 3H11.2

clone 3H11.2, from mouse

• 동의어(들): Retinal S-antigen, Rod photoreceptor arrestin, S-antigen, retina and pineal gland (arrestin), arrestin 1, retinal S-antigen (48 KDa protein)
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 항체 형태: saturated ammonium sulfate (SAS) precipitated
• 항체 생산 유형: primary antibodies
• 클론: 3H11.2, monoclonal
• 종 반응성: human
• 기술: immunofluorescence: suitable; western blot: suitable
• 동형: IgMκ
• NCBI 수납 번호: NP_004032.2
• UniProt 수납 번호: P49407
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... ARRB1(408)

설명

일반 설명

The Arrestin family consists of four members: Arrestin 1 (visual Arrestin), Arrestin 2 (beta Arrestin 1), Arrestin 3 (beta Arrestin 2), and Arrestin 4 (cone Arrestin). While visual and cone Arrestins are found almost exclusively in the retina, beta Arrestins 1 and 2 are ubiquitously expressed. Beta Arrestins appear to act as negative regulators on G protein-coupled receptors, (Lefkowitz, 1998). Interaction with molecules such as clathrin, AP-2 and NSF directs the clathrin-mediated internalization of G-protein-coupled receptors. Interaction with molecules such as Src, Raf, Erk, ASK1 and JNK3 appears to regulate several pathways that result in the activation of MAP kinases, (Lin, 1998; Miller, 2001).

특이성

Other species have not been tested.

Reacts with human beta-arrestin 1.

면역원

Epitope: a.a. 357-372

KLH conjugated synthetic peptide corresponding to amino acids 357-372 of human beta arrestin 1.

애플리케이션

Anti-beta Arrestin 1 Antibody, clone 3H11.2 detects level of beta Arrestin 1 & has been published & validated for use in WB & IF.

Research Category
Cell Structure

Research Sub Category
Sensory & PNS

G-proteins

품질

Evaluated on a representative lot by Western blot in HEK293 cell lysate.

표적 설명

~47 kDa

물리적 형태

Format: Purified

Purified in PBS with 0.05% NaN3.

저장 및 안정성

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

분석 메모

Control
HEK293 cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable