추천 제품
생물학적 소스
mouse
Quality Level
항체 형태
purified antibody
항체 생산 유형
primary antibodies
클론
7C6.D10, monoclonal
종 반응성
human
제조업체/상표
Chemicon®
기술
western blot: suitable
동형
IgG1κ
GenBank 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... SCRIB(23513)
일반 설명
Scribble is a tumor suppressor marker first discovered in Drosophila that has been implicated in the control of cell proliferation, polarity, invasion, and metastasis (Humbert, et al, 2003). Mammalian Scribble expresses basolateral staining in epithelial tissue and highly polarized expression in T lymphocytes (Dow, et al, 2003) (Ludford-Menting, et al, 2005), and plays an essential role in the regulation of the polarity specifically involved in directed epithelial migration. Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear (Dow, et al, 2007).
특이성
Predicted to cross react with mouse based on sequence homology. Reactivity with other species has not been tested.
면역원
Epitope: PDZ2 domain of Scribble
GST-tagged fusion protein corresponding to the PDZ2 domain of Scribble
애플리케이션
Suggested dilutions:
Western blot: 0.2 µg (1:2000)
Western blot: 0.2 µg (1:2000)
Research Sub Category
Tumor Markers
Cytoskeleton
Tumor Markers
Cytoskeleton
This Anti-Scribble Antibody is validated for use in WB for the detection of Scribble.
품질
Routinely evaluated by Western blot on HeLa cell lysates.
표적 설명
220 kDa
물리적 형태
Format: Purified
Purified in PBS containing with 0.05% NaN3.
저장 및 안정성
Maintain at 2-8°C for up to 1 year after date of receipt.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
GenBank is a registered trademark of United States Department of Health and Human Services
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
L E Dow et al.
Oncogene, 26(16), 2272-2282 (2006-10-18)
Altered expression of human Scribble is associated with invasive epithelial cancers, however, its role in tumour development remains unclear. Mutations in Drosophila Scribble result in loss of polarity, overproliferation and 3D-tumourous overgrowth of epithelial cells. Using complementation studies in Drosophila
Mandy J Ludford-Menting et al.
Immunity, 22(6), 737-748 (2005-06-21)
T cell shape is dictated by the selective recruitment of molecules to different regions of the cell (polarity) and is integral to every aspect of T cell function, from migration to cytotoxicity. This study describes a mechanism for the regulation
Lukas E Dow et al.
Oncogene, 22(58), 9225-9230 (2003-12-19)
Scribble (scrib), discs large (dlg) and lethal giant larvae (lgl) encode proteins that regulate cell polarity and have been identified as neoplastic tumour suppressor genes in Drosophila melanogaster. Here, we have used the Drosophila model system to provide the first
Patrick Humbert et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 25(6), 542-553 (2003-05-27)
Dlg (Discs large), Scrib (Scribble) and Lgl (Lethal giant larvae) are evolutionarily conserved components of a common genetic pathway that link the seemingly disparate functions of cell polarity and cell proliferation in epithelial cells. dlg, scrib and lgl have been
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.