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Merck
모든 사진(1)

Key Documents

GF308

Sigma-Aldrich

NT-3 Protein, Human Recombinant Animal Free

Recombinant animal free human NT-3 is manufactured using all non-animal reagents.

동의어(들):

NT3, Neurotrophin 3, HDNF, Nerve growth factor 2, Neurotrophic factor

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About This Item

UNSPSC 코드:
12352202
eCl@ss:
32160405
NACRES:
NA.77

재조합

expressed in E. coli

Quality Level

분석

>98% (SDS-PAGE and HPLC)

불순물

<0.1 μg/mg protein endotoxin (<1EU/μg)

UniProt 수납 번호

배송 상태

dry ice

일반 설명

Neurotrophin3 (NT3) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous systems. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT3, and NT4/5. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues).Human and Mouse NT-3 sequences are identical.
Product Source: E. coli

특이성

Cross Reactivty
None

애플리케이션

Recombinant animal free human NT-3 is manufactured using all non-animal reagents.
Research Category
Neuroscience
Research Sub Category
Growth Factors & Receptors

품질

Bioactivity assay: The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found in the range of 20-50 ng/ml.

물리적 형태

Product is filtered through a 0.2 micron filter before lyophilization. Product is presented in .
Recombinant animal free human NT-3 is manufactured using all non-animal reagents

저장 및 안정성

Store at -20°C for up to 6 months from date of receipt.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Samuel Lawn et al.
The Journal of biological chemistry, 290(6), 3814-3824 (2014-12-30)
Neurotrophins and their receptors are frequently expressed in malignant gliomas, yet their functions are largely unknown. Previously, we have shown that p75 neurotrophin receptor is required for glioma invasion and proliferation. However, the role of Trk receptors has not been

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