FCMAB288A6

Milli-Mark^® Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor^™647, clone Apu3

clone Apu3, Milli-Mark^®, from rabbit

• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.45
• 결합: ALEXA FLUOR^™ 647
• application: FACS
• 클론: Apu3, monoclonal
• 종 반응성: human
• 기술: flow cytometry: suitable

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: ALEXA FLUOR^™ 647
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: Apu3, monoclonal
• 종 반응성: human
• 제조업체/상표: Milli-Mark^®
• 기술: flow cytometry: suitable
• 동형: IgG
• UniProt 수납 번호: P0CG48
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... UBB(7314)

설명

일반 설명

Polyubiquitin chains linked through the Lys48 residue of ubiquitin are most commonly associated with proteins targeted for proteosomal degradation. In contrast, polyubiquitin chains linked through the Lys63 residue of ubiquitin (Ub) are associated with nonproteolytic functions such as signal transduction. Lys63-linked polyUb chains connect components of NFκB signaling in a highly regulated manner, and genetic evidence indicates the involvement of Lys63-linked Ub chains in stress response and DNA repair. Research in yeast has suggested Lys63-linked Ub chains stimulate endocytosis.

특이성

Recognizes ubiquitin linked at Lys63. Does not recognize ubiquitin linked at Lys48 or free ubiquitin.

면역원

Immunogen used was di-ubiquitin linked at Lys63.

애플리케이션

This Milli-Mark Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor647, clone Apu3 is validated for use in FC for the detection of Ubiquitin.

품질

Evaluated by flow cytometry using HeLa cells

표적 설명

Molecular weight varies.

물리적 형태

Purified recombinant rabbit monoclonal IgG1 conjugated to Alexa Fluor 647 in PBS with 0.1% sodium azide and 15 mg/mL BSA.

법적 정보

ALEXA FLUOR is a trademark of Life Technologies

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable