FCABS400F
Milli-Mark® Anti-FcεRI Antibody, γ subunit-FITC
Milli-Mark®, from rabbit
동의어(들):
Fc fragment of IgE high affinity I receptor for gamma polypeptide, Fc-epsilon RI-gamma, FceRI gamma, IgE Fc receptor subunit gamma, Immunoglobulin E receptor, high affinity,gamma chain
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모든 사진(1)
About This Item
UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41
추천 제품
생물학적 소스
rabbit
Quality Level
결합
FITC conjugate
항체 형태
purified immunoglobulin
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
mouse, human, rat
제조업체/상표
Milli-Mark®
기술
flow cytometry: suitable
동형
IgG
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... FCER1G(2207)
관련 카테고리
일반 설명
Type I allergic reactions are mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for type I allergic reactions. The FceRI receptor is a tetrameric complex, consisting of an a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.
특이성
Recognizes and is specific for FcεRI, γ-subunit.
면역원
Synthetic peptide corresponding to amino acids 80-86 of γ-subunit of Fc receptors.
애플리케이션
Milli-Mark Anti-FcεRI Antibody, γ subunit-FITC is an antibody against FcεRI for use in FC.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Inflammation & Autoimmune Mechanisms
Inflammation & Autoimmune Mechanisms
품질
Evaluated by flow cytometry using RBL cells.
표적 설명
10 kDa Calculated
물리적 형태
Protein A purified
Purified rabbit polyclonal IgG conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
저장 및 안정성
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
분석 메모
Control
RBL cells
RBL cells
기타 정보
Optimal working dilutions must be determined by end user for other instruments
Unconjugated antibody (Cat No. 06-727) has been shown to work on Human and Mouse.
법적 정보
MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Zeguang Wu et al.
Journal of immunology (Baltimore, Md. : 1950), 207(10), 2534-2544 (2021-10-10)
Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection promotes NK cells with
Spandan V Shah et al.
Cell reports, 25(10), 2766-2774 (2018-12-06)
Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain (Δg) acquire adaptive features, including robust proliferation, multifunctionality, rapid
Alexander Rölle et al.
Cell reports, 24(8), 1967-1976 (2018-08-23)
Adaptive NK cells are characterized by profound alterations in multiple signaling molecules, transcription factors, and epigenetic modifications compared with canonical NK cells. Although their existence is associated with prior exposure to human cytomegalovirus (HCMV), key questions regarding their regulation and
Jens H W Pahl et al.
Cancer immunology research, 6(5), 517-527 (2018-03-09)
CD16A is a potent cytotoxicity receptor on human natural killer (NK) cells, which can be exploited by therapeutic bispecific antibodies. So far, the effects of CD16A-mediated activation on NK cell effector functions beyond classical antibody-dependent cytotoxicity have remained poorly elucidated.
Avishai Shemesh et al.
The Journal of experimental medicine, 219(11) (2022-09-07)
Human adaptive-like natural killer (NK) cells express low levels of FcεRIγ (FcRγ-/low) and are reported to accumulate during COVID-19 infection; however, the mechanism underlying and regulating FcRγ expression in NK cells has yet to be fully defined. We observed lower
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