AG938

Synuclein, α, recombinant human

• 동의어(들): α-Synuclein protein, Alpha Synuclein
• UNSPSC 코드: 12352200
• eCl@ss: 32160405
• NACRES: NA.41

속성

• 생물학적 소스: human
• Quality Level: 100
• 분석: >95% (gel scan and mass spectrometry)
• 형태: solid
• 유통기한: 12 mo.
• 제조업체/상표: Chemicon^®
• solubility: water: slightly soluble
• 적합성: suitable for molecular biology
• NCBI 수납 번호: NM_000345.2; NM_007308.1
• UniProt 수납 번호: P37840
• 유전자 정보: human ... SNCA(6622)

설명

일반 설명

Research area: Neuroscience

α-Synuclein, a member of the synuclein family of proteins that localize to presynaptic terminals under physiological conditions. It is comprised of three primary regions: an amino terminus containing apolipoprotein lipid-binding motifs, which are anticipated to form amphiphilic helices. The central region, known as non-Aβ component (NAC) containing a hydrophobic domain that gives β-sheet potential, and the carboxyl terminus, characterized by a high negative charge and remains unstructured. Under physiological conditions, members of the synuclein family, including α-synuclein, are predominantly neuronal proteins.

애플리케이션

Synuclein, α, recombinant human has been used:

• for preparation of α-synuclein fibrils to access the SAR228810 antibody against the risk of amyloid-related imaging abnormalities (ARIA).
• to study the formation of isoasparate protein damage responsible to trigger familial Parkionsonian phenotypes.
• to study its interaction with iron and copper, in order to understand their role in proteinopathies.

생화학적/생리학적 작용

Synuclein, α is the principal component of Lewy bodies and a pathological hallmark of synucleinopathies, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). The deposition of αS aggregates is a defining characteristic of all these diseases.

물리적 형태

Lyophilized from TBS. Resuspend in water at a concentration of 1 mg/mL.

저장 및 안정성

Maintain lyophilized material at -20ºC for up to 12 months after date of receipt. After reconstitution maintain at -20ºC to -70ºC for up to 2 weeks in undiluted aliquots. Avoid freeze/thaw cycles to avoid aggregation.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable