ABS94

Anti-MLK1 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Mitogen-activated protein kinase kinase kinase 9, Mixed lineage kinase 1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 종 반응성(상동성에 의해 예측): chimpanzee (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
• 기술: immunohistochemistry: suitable (paraffin)
• NCBI 수납 번호: NP_149132
• UniProt 수납 번호: P80192
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... MAP3K9(4293)

설명

일반 설명

MLK1 (MAP3K9) is a serine–threonine kinase of the Mixed-Lineage Kinase (MLK) family capable of activating the c-Jun N-terminal Kinase (JNK)/Mitogen-Activated Protein Kinase (MAPK) pathway and regulating the other two prinicpal MAPK cascades, p38 and extracellular signal regulated kinase (ERK). Immunoblots and mass spectrometry show MLK is threonine phosphorylated in or near the activation loop. Studies show that MLKs play a role in the TGF-beta1-induced cell death mechanism.

면역원

KLH-conjugated linear peptide corresponding to human MLK1.

애플리케이션

Anti-MLK1 Antibody detects level of MLK1 & has been published & validated for use in IH(P).

Research Category
Signaling

Research Sub Category
Kinases & Phosphatases

품질

Evaluated by Immunohistochemistry in colorectal adenocarcinoma tissue.

Immunohistochemistry Analysis: A 1:300 dilution of this antibody detected MLK1 in colorectal adenocarcinoma tissue.

표적 설명

121 kDa (isoform 1), 123 kDa (isoform 2) calculated

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Colorectal adenocarcinoma tissue

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids