ABS523

Anti-Lipin-1 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Phosphatidate phosphatase LPIN1, Lipin-1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: mouse, human
• 기술: immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• NCBI 수납 번호: NP_001248356
• UniProt 수납 번호: Q14693
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... LPIN1(23175)

설명

일반 설명

Lipin-1 is also called Phosphatidate phosphatase LPIN1. Lipin-1 controls the metabolism of fatty acids, acts as a magnesium-dependent phosphatidate phosphatase enzyme, as well as a nuclear transcriptional coactivator that modulates lipid metabolism gene expression. Lipin-1 involved in adipocyte differentiation, and is also potentially involved in mitochondrial fission. Lipin-1 is specifically expressed in skeletal muscle, and is also abundant in adipose tissue. Lipin-1 defects can cause autosomal recessive acute recurrent myoglobinuria (ARARM).

면역원

linear peptide corresponding to human Lipin-1.

애플리케이션

Anti-Lipin-1 Antibody is an antibody against Lipin-1 for use in IHC, western blotting & IP.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Lipin-1 in human cardiac myocytes and human skeletal muscle myocytes tissue.
Western Blotting Analysis: A representative lot detected Lipin-1 in mouse adipose tissue lysate (Mayurranjan, S., et al. (2013). PNAS. 110(2):642-647).
Immunoprecipitation Analysis: A representative lot immunoprecipitated Lipin-1 in adipose tissue lysate (Mayurranjan, S., et al. (2013). PNAS. 110(2):642-647).

Research Category
Signaling

Research Sub Category
Lipid Metabolism & Weight Regulation

품질

Evaluated by Western Blotting in mouse hepatocytes overexpressing lipin1 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Lipin-1 in 10 µg of mouse hepatocytes overexpressing lipin1 cell lysate (lysate from the laboratory of Brian Finck, Washington University, St. Louis).

표적 설명

~ 110 kDa observed

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide with 50% glycerol.

저장 및 안정성

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2