ABN99

Anti-phospho NR1 (Ser897) Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): glutamate receptor, ionotropic, N-methyl D-aspartate 1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta 1, N-methyl-D-aspartate receptor channel, subunit zeta-1, glutamate [NMDA] receptor subunit zeta-1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: rat
• 종 반응성(상동성에 의해 예측): mouse (based on 100% sequence homology), human (based on 100% sequence homology)
• 기술: immunohistochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• UniProt 수납 번호: Q05586
• 배송 상태: wet ice
• 타겟 번역 후 변형: phosphorylation (pSer897)
• 유전자 정보: human ... GRIN1(2902) ; mouse ... Grin1(14810) ; rat ... Grin1(24408)

설명

일반 설명

NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory.

특이성

This antibody recognizes NR1 when phosphorylated at Ser897.

면역원

Epitope: Phosphorylated Ser897

KLH-conjugated linear peptide corresponding to rat NR1 when phosphorylated at Ser897.

애플리케이션

Immunohistochemistry Analysis: 1:50 dilution from a previous lot detected NR1 in normal rat hippocampus.
Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated NR1 from rat brain microsomal RIPA lysate.
Western Blot Analysis: 2 µg/mL from a previous lot detected NR1 in Lambda phosphatase untreated and treated rat brain microsomal tissue lysate.

Research Category
Neuroscience

Research Sub Category
Signaling Neuroscience

This Anti-phospho NR1 (Ser897) Antibody is validated for use in WB, IP, IH for the detection of phospho NR1 (Ser897).

품질

Evaluated by Western Blot in rat brain microsomal tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected NR1 on 10 µg of rat brain microsomal tissue lysate.

표적 설명

~ 120 kDa

결합

Replaces: 06-641

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Rat brain microsomal tissue lysate

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable