ABN87

Anti-DSCR3 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Down syndrome critical region protein 3, Down syndrome critical region protein A
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 기술: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI 수납 번호: NP_006043
• UniProt 수납 번호: O14972
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... VPS26C(10311)

설명

일반 설명

Trisomy of human chromosome 21 result in patients with Down′s syndrome, which is a complex developmental and neurodegenerative disease that is characterized with abnormal morphological features, hypotonia, and mental retardation. The DSCR3 (Down syndrome critical region gene 3) gene is found in this region. DSCR3 expresses Down syndrome critical region protein 3, which is reportedly expressed in many studied tissues. While it is suggested that this protein is involved in neuroexcitation and in cellular signaling, further study is still required to elucidate its role and mechanism of action.

특이성

Other homologies: Rat and Mouse (92% sequence homology).

면역원

KLH-conjugated linear peptide corresponding to human DSCR3.

애플리케이션

Immunohistochemistry Analysis: A 1:200 dilution from a representative lot detected DSCR3 in human gastric tissue.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

This Anti-DSCR3 Antibody is validated for use in WB, IH(P) for the detection of DSCR3.

품질

Evaluated by Western Blot in A549 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected DSCR3 in 10 µg of A549 cell lysate.

표적 설명

~39 kDa observed. An uncharacterized band may be observed at a molecular weight of ~160 kDa in some cell lysates.

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
A549 cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable