ABN645

Anti-RIM 2 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Regulating synaptic membrane exocytosis protein 2, Rab-3-interacting molecule 2, RIM 2, Rab-3-interacting protein 3
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: rat, human
• 기술: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• UniProt 수납 번호: Q9UQ26
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... RIMS2(9699)

설명

일반 설명

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM 1 and RIM 2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM 1, RIM 2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

특이성

This antibody may recognize many isoforms and is predicted to have no cross-reactivity to other RIM proteins.

면역원

Epitope: center region

KLH-conjugated synthetic peptide corresponding to the center region of human RIM 2.

애플리케이션

Anti-RIM 2 Antibody is an antibody against RIM 2 for use in western blotting, IHC & immunofluorescence.

Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected RIM 2 in human brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected RIM 2 in human brain cells.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

품질

Evaluated by Western Blotting in rat brain tissue lysate with and without blocking peptide.

Western Blotting Analysis: 1 μg/mL of this antibody detected RIM 2 in rat brain tissue lysate with and without blocking peptide.

표적 설명

~86 kDa observed. Uniprot describes 3 isoforms produced by alternative splicing ranging between ~31 kDa and ~160 kDa

물리적 형태

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable