추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
정제법
affinity chromatography
종 반응성
mouse, human
기술
immunohistochemistry: suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... DAGLA(747)
일반 설명
The protein DGL-alpha is a lipase enzyme that catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG) endocannabinoid in tissues. Endocannabinoids are a group of lipid-like molecules that are neuromodulatory in nature and are involved in the control of many physiological functions including appetite, pain sensation, mood, and memory. They also mediate the psychoactive effects of cannabis (marijuana). Endocannabinoids (ECs) act as retrograde messengers that enable postsynaptic cells to regulate the strength of their synaptic inputs. DGL-alpha is also an excellent marker for cerebellum as DGL-alpha is highly expressed in cerebellum and necessary for the regulation of synaptic retrograde transmission in the cerebellum, hippocampus and striatum, as well as other regions including the auditory brainstem.
면역원
Recombinant protein corresponding to the cytoplasmic domain of human DGL-α.
애플리케이션
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DGL-α in human cerebellum and mouse cerebellum tissue.
Immunohistochemistry Analysis: A representative lot detected DGL-α in mouse brain tissue (Berghuis, P., et al. (2007). Science. 316:1212-1216).
Immunohistochemistry Analysis: A representative lot detected DGL-α in mouse brain tissue (Berghuis, P., et al. (2007). Science. 316:1212-1216).
This Anti-DGL-α Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of DGL-α.
품질
Evaluated by Western Blotting in mouse cerebellum tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected DGL-α in 10 µg of mouse cerebellum tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected DGL-α in 10 µg of mouse cerebellum tissue lysate.
표적 설명
~110 kDa observed. Uncharacterized band(s) may appear in some lysates.
기타 정보
Concentration: Please refer to lot specific datasheet.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
B A S Reyes et al.
Neuroscience, 303, 323-337 (2015-07-15)
Endocannabinoids (eCBs) are involved in a myriad of physiological processes that are mediated through the activation of cannabinoid receptors, which are ubiquitously distributed within the nervous system. One neurochemical target at which cannabinoids interact to have global effects on behavior
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