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Merck
모든 사진(2)

주요 문서

ABE1008

Sigma-Aldrich

Anti-Ligand-dependent nuclear receptor-interacting factor 1 Antibody

0.5 mg/mL, from rabbit

동의어(들):

Ligand-dependent nuclear receptor-interacting factor 1, LRIF1, RIF1, C1orf103, Receptor-interacting factor 1

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

정제법

affinity chromatography

종 반응성

human, mouse

종 반응성(상동성에 의해 예측)

primate (based on 100% sequence homology)

농도

0.5 mg/mL

기술

immunocytochemistry: suitable
western blot: suitable

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... LRIF1(55791)

일반 설명

Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1), also known as RIF1, Receptor-interacting factor 1, and is encoded by the gene LRIF1/C1orf103/RIF1. The retinoic acid receptors (RARs) are ligand-dependent transcription factors that play critical roles in cell differentiation, embryonic development, and tumor suppression. RAR transcriptional activities are mediated by a growing family of nuclear receptor (NR) coregulators. Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) is such a coregulator. Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) is a repressor of ligand-induced transcriptional activity of retinoic receptor alpha. Ligand-dependent nuclear receptor-interacting factor 1 (LRIF1) is ubiquitously expressed in a wide variety of tissues and cells and localizes exclusively to the nucleus and specifically to the nuclear matrix.

면역원

Epitope: Near C-terminus
KLH-conjugated linear peptide corresponding to a region near the C-terminus of human Ligand-dependent nuclear receptor-interacting factor 1.

애플리케이션

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected Ligand-dependent nuclear receptor-interacting factor 1 in HeLa, A431, HepG2, and NIH/3T3 cells.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Chromatin Biology
This Anti-Ligand-dependent nuclear receptor-interacting factor 1 Antibody is validated for use in western blotting & ICC for the detection of Ligand-dependent nuclear receptor-interacting factor 1.

품질

Evaluated by Western Blotting in SH-SY5Y cell lysate.

Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Ligand-dependent nuclear receptor-interacting factor 1 in 10 µg of SH-SY5Y cell lysate.

표적 설명

~100 kDa observed

물리적 형태

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Darina Šikrová et al.
Communications biology, 6(1), 677-677 (2023-06-29)
Facioscapulohumeral muscular dystrophy (FSHD) is caused by the epigenetic derepression of the 4q-linked D4Z4 macrosatellite repeat resulting in inappropriate expression of the D4Z4 repeat-encoded DUX4 gene in skeletal muscle. In 5% of FSHD cases, D4Z4 chromatin relaxation is due to

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