ABC837

Anti-ARC Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Nucleolar protein 3, Apoptosis repressor with CARD, Muscle-enriched cytoplasmic protein, Myp, Nucleolar protein of 30 kDa, Nop30, ARC
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 기술: immunohistochemistry: suitable; western blot: suitable
• UniProt 수납 번호: O60936
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... NOL3(8996)

설명

일반 설명

Nucleolar protein 3 (NOL3), also known as Apoptosis repressor with CARD or Muscle-enriched cytoplasmic protein (Myp) or Nucleolar protein of 30 kDa (Nop30) and encoded by the gene name NOL3 or ARC contains one CARD domain. Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD. ARC interacts with caspase-2 and –8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.

면역원

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to amino acids 191-208 at the C-terminus of human ARC.

애플리케이션

Anti-ARC Antibody detects level of ARC & has been published & validated for use in ARC.

Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected ARC in human heart and skeletal muscle tissues.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

품질

Evaluated by Western Blotting in HeLa, KB, and A549 cell lysates.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected ARC in HeLa, KB, and A549 cell lysates.

표적 설명

~24 kDa observed. Uncharacterized bands may be observed in some lysate(s).

물리적 형태

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable