ABC830

Anti-SEC62 Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Translocation protein SEC62, Translocation protein 1, TP-1, hTP-1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• 클론: polyclonal
• application: IHC; WB
• 종 반응성: mouse, rat
• 기술: immunohistochemistry: suitable; western blot: suitable

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: mouse, rat
• 기술: immunohistochemistry: suitable; western blot: suitable
• UniProt 수납 번호: Q99442
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... SEC62(7095)

설명

일반 설명

Translocation protein SEC62, also known as Translocation protein 1 (TP-1) or (hTP-1), and encoded by the gene name SEC62, is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex. This complex is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.

특이성

This antibody is predicted to not cross-react with other SEC proteins.

면역원

Epitope: C-terminus

KLH-conjugated synthetic peptide corresponding to the C-terminus of human SEC62.

애플리케이션

Anti-SEC62 Antibody detects level of SEC62 & has been published & validated for use in SEC62.

Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected SEC62 in mouse brain tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

품질

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 0.5 μg/mL of this antibody detected SEC62 in rat brain tissue lysate.

표적 설명

~31 and ~43 kDa observed. Uncharacterized bands may be observed in some lysate(s).

물리적 형태

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable