추천 제품
일반 설명
TMPK, also known as dTMP kinase, and encoded by the gene DTYMK/CDC8/TMPK/TYMK, is a key enzyme for pyrimidine synthesis that catalyzes the phosphorylation of thymidine 5′-monophosphate (dTMP) to form thymidine 5′-diphosphate (dTDP). TMPK has important functions in cell proliferation and DNA replication, and the synthesis of dTDP is unique because it requires TMPK. All other dNDPs are directly produced by ribonucleotide reductase (RNR). Thus, TMPK is well recognized as a potential drug target for many diseases and disease agents including viruses. TMPK is currently a target of anti-HIV nucleoside therapy, and TMPK is also a validated target for antibiotic development against resistance strains of bacteria and parasites, and research demonstrates that it may also be a good target for the anticancer agent doxorubicin cancer cells. Expressed by virtually all cells it is localized to cell cytoplasm with only traces found in Golgi, mitochondria and nuclei.
면역원
GST-tagged recombinant protein corresponding to human Thymidylate Kinase/TMPK.
애플리케이션
Anti-Thymidylate Kinase/TMPK Antibody is a rabbit polyclonal antibody, validated for use in western blotting & IP.
Research Category
Apoptosis & Cancer
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional
Apoptosis - Additional
Western Blotting Analysis: A representative lot from an independent laboratory detected Thymidylate Kinase/TMPK in MDA-MB231, MCF-7, H184B5F5/M10 cell lysates (Hu, C. M., et al. (2012). Cancer Cell. 22(1):36-50.).
Immunoprecipitation Analysis: A representative lot from an independent laboratory immunprecipitated Thymidylate Kinase/TMPK from MCF-7, H184B4F5/M10, and MCF-10A cell lysates (Ke, P. Y., et al. (2005). Genes Dev. 19(16):1920-1933.).
Western Blotting Analysis: A representative lot from an independent laboratory detected Thymidylate Kinase/TMPK in MCF-7, H184B4F5/M10, and MCF-10A cell lysates (Ke, P. Y., et al. (2005). Genes Dev. 19(16):1920-1933.).
Immunoprecipitation Analysis: A representative lot from an independent laboratory immunprecipitated Thymidylate Kinase/TMPK from MCF-7, H184B4F5/M10, and MCF-10A cell lysates (Ke, P. Y., et al. (2005). Genes Dev. 19(16):1920-1933.).
Western Blotting Analysis: A representative lot from an independent laboratory detected Thymidylate Kinase/TMPK in MCF-7, H184B4F5/M10, and MCF-10A cell lysates (Ke, P. Y., et al. (2005). Genes Dev. 19(16):1920-1933.).
품질
Evaluated by Western Blotting in Jurkat cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected Thymidylate Kinase/TMPK in 10 µg of Jurkat cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected Thymidylate Kinase/TMPK in 10 µg of Jurkat cell lysate.
표적 설명
~24 kDa observed
물리적 형태
Format: Purified
Protein A purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Stable for 1 year at 2-8°C from date of receipt.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Control of dTTP pool size by anaphase promoting complex/cyclosome is essential for the maintenance of genetic stability.
Ke, Po-Yuan, et al.
Genes & Development, 19, 1920-1933 (2005)
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