ABC337

Anti-BAFF receptor Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor, BAFF receptor, BAFF-R, BLyS receptor 3, CD268
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: rat, human, mouse
• 기술: immunohistochemistry: suitable; western blot: suitable
• UniProt 수납 번호: Q96RJ3
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... TNFRSF13C(115650)

설명

일반 설명

B-cell-activating factor receptor (BAFF receptor, BAFF-R), also known as tumor necrosis factor receptor superfamily member 13C (TNFRSF13C) and BLyS receptor 3 (BR3), is a member of the TNF superfamily that regulate immune responses and induce apoptosis. BAFF receptor promotes the survival of mature B-cells and the B-cell response. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF-kB and c-jun N-terminal kinase. BAFF receptor is highly expressed in spleen and lymph node, with lower levels found in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes. Mutations in BAFF receptor have been associated with immunodeficiency common variable type 4 (CVID4), also called BAFFR defect.

특이성

This antibody recognizes the C-terminus of BAFF receptor.

면역원

KLH-conjugated linear peptide corresponding to the C-terminus of human BAFF receptor.

애플리케이션

Detect B-cell-activating factor receptor using this rabbit polyclonal antibody, Anti-BAFF receptor Antibody validated for use in western blotting & IHC.

Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected BAFF receptor in human tonsil tissue.

품질

Evaluated by Western Blotting in human, mouse, and rat spleen tissue lysates.

Western Blotting Analysis: 5 µg/mL of this antibody detected BAFF receptor in 15 µg of human, mouse, and rat spleen tissue lysates.

표적 설명

~22 kDa observed. Uniprot describes two isoforms at ~19 kDa Uncharacterized bands may appear in some lysates.

분석 메모

Control
Human, mouse, and rat spleen tissue lysates

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable