AB5932

Anti-Potassium Channel KvLQT1 Antibody, CT

Chemicon^®, from rabbit

• 동의어(들): IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1, KQT-like 1, Voltage-gated potassium channel subunit Kv7.1, kidney and cardiac voltage dependent K+ channel, potassium voltage-gated channel, KQT-like subfamily, member 1, slow delay
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: human
• 종 반응성(상동성에 의해 예측): mouse (based on 100% sequence homology), rat (based on 100% sequence homology)
• 제조업체/상표: Chemicon^®
• 기술: immunohistochemistry: suitable; western blot: suitable
• NCBI 수납 번호: NP_000209.2
• UniProt 수납 번호: P51787
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... KCNQ1(3784)

설명

일반 설명

KvLQT1(Kv7.1) is a voltage-gated potassium channel protein coded for by the gene KCNQ1. This protein is present in the cell membranes of cardiac muscle tissue and in inner ear neurons among other tissues. KvLQT1 can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3 and in heart cells is required for the repolarization phase of the cardiac action potential. Mutations in the gene are associated with hereditary long QT syndrome, Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation, lead to a defective KvLQT1 protein and several forms of inherited arrhythmias known as Long QT syndrome, Short QT syndrome, and Familial Atrial Fibrillation.

특이성

This antibody recognizes Potassium Channel KvLQT1 protein.

면역원

Epitope: C-terminus

KLH-conjugated linear peptide from the C-terminus of human KvLQT1.

애플리케이션

Anti-Potassium Channel KvLQT1 Antibody, C-terminus detects level of Potassium Channel KvLQT1 & has been published & validated for use in IH & WB.

Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected Potassium Channel KvLQT1 in human myocardium tissue.

/Western Blotting Analysis: 2 μg/mL of this
antibody detected KvLQT1 in 10 μg of human
heart tissue lysate.

Optimal working dilutions must be determined by end user.

Research Category
Neuroscience

Research Sub Category
Ion Channels & Transporters

품질

Evaluated by Western Blot in human heart tissue lysate.

Western Blot Analysis: 2 µg/ml of this antibody detected KvLQT1 in 10 µg of human heart tissue lysate.

표적 설명

~ 72 kDa Observed

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
Human heart tissue lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable