추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
affinity purified immunoglobulin
항체 생산 유형
primary antibodies
클론
polyclonal
정제법
affinity chromatography
종 반응성
human, mouse, rat
제조업체/상표
Chemicon®
기술
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
human ... KCNH2(3757)
일반 설명
ERG1 encodes the pore forming alpha subunit of the voltage-gated channels that conduct the rapid delayed rectifier potassium current, which leads to termination of the cardiac ventricular action potential. A large number of commercially available therapeutic agents (antiarrhythmics, antihistamines, antibiotics and antidepressants) have been shown to preferentially block ERG1 and cause a disorder of cardiac action potential depolarization that predisposes affected individuals to ventricular arrhythmia and sudden death.
특이성
ERG1 protein. By western blot, antibody recognizes bands at 175 and 205 kDa (glycosylated) or 135 and 165 kDa (deglycosylated).
면역원
Epitope: C-terminus
Synthetic peptide corresponding to the C-terminus of ERG1 (aa 1145-1159 of HERG1).
애플리케이션
Anti-Potassium Channel ERG1 Antibody, C-terminus detects level of Potassium Channel ERG1 & has been published & validated for use in IC, IH, IP & WB.
Immunoblotting: 5 μg/mL
Immunocytochemistry
Immunohistochemistry on 4% paraformaldehyde fixed tissues.
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Immunocytochemistry
Immunohistochemistry on 4% paraformaldehyde fixed tissues.
Immunoprecipitation
Optimal working dilutions must be determined by end user.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Ion Channels & Transporters
Ion Channels & Transporters
물리적 형태
Liquid in PBS with 0.1% sodium azide.
저장 및 안정성
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles
분석 메모
Control
Positive control tissue: Heart
Positive control tissue: Heart
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
A L Pond et al.
The Journal of biological chemistry, 275(8), 5997-6006 (2000-02-22)
One form of inherited long QT syndrome, LQT2, results from mutations in HERG1, the human ether-a-go-go-related gene, which encodes a voltage-gated K(+) channel alpha subunit. Heterologous expression of HERG1 gives rise to K(+) currents that are similar (but not identical)
CD31 delays phagocyte membrane repolarization to promote efficient binding of apoptotic cells.
Vernon-Wilson, EF; Aurade, F; Tian, L; Rowe, IC; Shipston, MJ; Savill, J; Brown, SB
Journal of Leukocyte Biology null
Sönke Cordeiro et al.
PloS one, 6(12), e29490-e29490 (2011-12-30)
In response to light, most retinal neurons exhibit gradual changes in membrane potential. Therefore K+ channels that mediate threshold currents are well-suited for the fine-tuning of signal transduction. In the present study we demonstrate the expression of the different Kv11
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