추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
affinity purified immunoglobulin
클론
polyclonal
정제법
affinity chromatography
종 반응성
mouse
제조업체/상표
Chemicon®
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
일반 설명
Sox 10 is part of a family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Sox 10 is expressed in multipotent neural crest stem cells, and its expression is downregulated upon their differentiation. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.
특이성
Sox10. The immunogen sequence is 70% conserved with Sox8 and Sox9 and therefore the antibody may show cross reactivity to these proteins.
면역원
Synthetic peptide from Sox10.
애플리케이션
Anti-Sox10 Antibody detects level of Sox10 & has been published & validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Neuronal & Glial Markers
Developmental Neuroscience
Neuronal & Glial Markers
Western blot: 0.1-0.5 μg/mL using ECL on fetal mouse brain tissue lysate. The antibody reacts with proteins of ~60 kDa. An additional band of ~120 kDa may also be seen depending on sample used.
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
표적 설명
Approx. 55 kDa
결합
Replaces: AB5774
물리적 형태
Affinity purified immunoglobulin. Liquid.
저장 및 안정성
Maintain at +2-8°C in undiluted aliquots for up to 6 months after date of receipt.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS.
Koenning, M; Jackson, S; Hay, CM; Faux, C; Kilpatrick, TJ; Willingham, M; Emery, B
The Journal of Neuroscience null
Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury.
Keirstead, Hans S, et al.
The Journal of Neuroscience, 25, 4694-4705 (2005)
Potassium channel Kir 4.1 regulates oligodendrocyte differentiation via intracellular pH regulation.
Na Wang et al.
Glia, 70(11), 2093-2107 (2022-07-02)
In humans, loss-of-function mutations of Kcnj10 in SeSAME/EAST syndrome, which encodes the inwardly rectifying K+ channel 4.1 (Kir 4.1), causes progressive neurological decline. Despite its rich expression in oligodendrocyte (OL) lineage cells and an emerging link with demyelinating disease, the
Kyohei Fujita et al.
The FEBS journal, 283(20), 3791-3806 (2016-10-21)
Neural crest-derived stem cells (NCSCs) are tissue-specific stem cells derived from multipotent neural crest cells. NCSCs are present in some adult tissues such as dorsal root ganglia, sciatic nerve, and bone marrow. However, little is known about the formation mechanisms
Liang Zhou et al.
eLife, 9 (2020-01-17)
Oligodendrocytes (OLs) myelinate axons and provide electrical insulation and trophic support for neurons in the central nervous system (CNS). Platelet-derived growth factor (PDGF) is critical for steady-state number and differentiation of oligodendrocyte precursor cells (OPCs), but its downstream targets are
문서
Human iPSC neural differentiation media and protocols used to generate neural stem cells, neurons and glial cell types.
Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.
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