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AB10516

Sigma-Aldrich

Anti-Angiopoietin-1 Antibody

from rabbit

동의어(들):

Hepatic fibrinogen/angiopoietin-related protein, PPARG angiopoietin related protein, angiopoietin-like 4, angiopoietin-like 4 protein, angiopoietin-related protein 4, fasting-induced adipose factor, hepatic angiopoietin-related protein, peroxisome prolif

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About This Item

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

100

항체 형태

affinity isolated antibody

항체 생산 유형

primary antibodies

클론

polyclonal

종 반응성

horse (95% sequence homology), dog (95% sequence homology), mouse (100% sequence homology), rat (95% sequence homology), bovine (95% sequence homology), mouse, human (90% sequence homology), pig (95% sequence homology)

기술

western blot: suitable

NCBI 수납 번호

NM_001146.3

UniProt 수납 번호

O08538

배송 상태

wet ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... ANGPT1(284)

일반 설명

The remodelling of the primitive vasculature in mammals to form the mature cardiovascular system includes a number of factors directing endothelial cell development. Angiopoietin-1 is an angiogenic secreted protein that interacts with the endothelial specific Tie-2 receptor. It is primarily expressed in developing endothelial cells. During embryonic development, Ang-1 binds and induces tyrosine phosphorylation of Tie-2. Ang-1 appears to play a crucial role in mediating matrix and mesenchyme. It mediates blood vessel maturation and stability. Ang-1 may play a critical role in heart development. Ang-1 deficient mice mimic the phenotype exhibited by animals deficient in Tie-2. A homolog of Ang-1, termed Angiopoietin-2 may act as an antagonist for Ang-1 and Tie-2. Ang-1 and Ang-2 have ~60% sequence homology.

특이성

This antibody recognizes Angiopoietin-1.

면역원

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from mouse Angiopoietin-1.

애플리케이션

Anti-Angiopoietin-1 Antibody is an antibody against Angiopoietin-1 for use in WB.

품질

Evaluated by Western Blot in mouse kidney lysate.
Western Blot Analysis: : 1:1,000 dilution of this lot detected Angiopoietin-1 on 10 µg of mouse kidney lysate.

표적 설명

57 kDa

물리적 형태

Format: Purified

분석 메모

Control
Mouse kidney lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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Frontiers in neuroscience, 13, 701-701 (2019-07-30)
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Respiratory research, 16, 4-4 (2015-01-17)
Earlier studies have reported that transforming growth factor beta 1(TGFβ1) is a critical mediator of hyperoxia-induced acute lung injury (HALI) in developing lungs, leading to impaired alveolarization and a pulmonary phenotype of bronchopulmonary dysplasia (BPD). However, the mechanisms responsible for
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Experimental & molecular medicine, 50(9), 117-117 (2018-09-07)
We have previously demonstrated that in response to cerebral ischemia (CI), the growth factor angiopoietin-1 (Ang1) and α5β1 integrin are both induced in cerebral vessels, which likely provide positive signals driving the endogenous angiogenic response and vascular protection after CI.
Kunio Kawamura et al.
PloS one, 9(6), e98639-e98639 (2014-06-05)
An angiogenesis factor, angiopoietin-1 (Ang1), is associated with the blood-brain barrier (BBB) disruption after focal cerebral ischemia. However, whether hemorrhagic transformation and cerebral edema after tissue plasminogen activator (tPA) treatment are related to the decrease in Ang1 expression in the

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