추천 제품
제품명
Fmoc-Cys(Trt)-NovaSyn® TGT, Novabiochem®
Quality Level
제품 라인
NovaSyn® TG
Novabiochem®
양식
solid
반응 적합성
reaction type: Fmoc solid-phase peptide synthesis
제조업체/상표
Novabiochem®
응용 분야
peptide synthesis
작용기
Fmoc
저장 온도
15-25°C
일반 설명
Pre-loaded resin for synthesis of peptide acids and protected peptide fragments containing a C-terminal cysteine amino-acid residue by Fmoc SPPS. The base NovaSyn® TG is a composite of low cross-linked polystyrene and 3000-4000 M.W. polyethylene glycol. Peptide synthesis is carried out at the ends of the PEG chains that have been functionalized with the hyper-acid labile 4-carboxytrityl alcohol linker. This use of this linker helps prevent racemization and β-piperidinylalanine formation during chain extension.Treatment of the peptidyl resin with 20% TFE in DCM or 1% TFA in DCM cleaves the product from the resin without affecting the standard TFA-labile side-chain protecting groups. Standard TFA cleavage releases the fully deprotected peptide.
Associated Protocols and Technical Articles:
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references:
[1] E. Atherton, et al. in "Peptides 1990, Proc. 21st European Peptide Symposium, E. Giralt & D. Andreu(Eds), 1991, Escom, Leiden, pp. 243
[2] J. Lukszo, et al. (1996) Lett. Pept. Sci., 3, 157.
[3] Y. Fujiwara, et al. (1994) Chem. Pharm. Bull., 42, 724.
[4] K. Barlos & D. Gatos in “Fmoc solid phase peptide synthesis: a practical approach”, W. C. Chan & P. D.White (Eds.), Oxford University Press, Oxford, 2000, pp. 218.
Associated Protocols and Technical Articles:
Cleavage and Deprotection Protocols for Fmoc SPPS
Literature references:
[1] E. Atherton, et al. in "Peptides 1990, Proc. 21st European Peptide Symposium, E. Giralt & D. Andreu(Eds), 1991, Escom, Leiden, pp. 243
[2] J. Lukszo, et al. (1996) Lett. Pept. Sci., 3, 157.
[3] Y. Fujiwara, et al. (1994) Chem. Pharm. Bull., 42, 724.
[4] K. Barlos & D. Gatos in “Fmoc solid phase peptide synthesis: a practical approach”, W. C. Chan & P. D.White (Eds.), Oxford University Press, Oxford, 2000, pp. 218.
애플리케이션
Applications of Fmoc-Cys(Trt)-NovaSyn® TGT include:
- the preparation of a phosphoprotein using Native Chemical Ligation (NCL).
- the preparation of a peptide intermediate for use in glycoprotein semi-synthesis.
결합
Replaces: 04-12-2705
법적 정보
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
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