681636-M

W-13, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

• 동의어(들): W-13, Hydrochloride, N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl
• 실험식(Hill 표기법): C₁₄H₁₇ClN₂O₂S · xHCl
• CAS Number: 88519-57-7
• Molecular Weight: 312.81 (free base basis)
• MDL number: MFCD00058030
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: water: 35 mg/mL
• 저장 온도: 2-8°C
• InChI: 1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H
• InChI key: QKAALLVQBOLELJ-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable and reversible calmodulin antagonist that inhibits Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM) and myosin light chain kinase (IC₅₀ = 58 µM).

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 58 µM) and Ca²⁺-calmodulin-dependent phosphodiesterase (IC₅₀ = 68 µM).

생화학적/생리학적 작용

Target IC₅₀: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase

경고

Toxicity: Standard Handling (A)

분석 메모

single spot by TLC

기타 정보

Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable