647926-M

Trichostatin A, Streptomyces sp.

InSolution, ≥98%, reversible inhibitor of histone deacetylase

• 동의어(들): InSolution Trichostatin A, Streptomyces sp., 4,6-Dimethyl-7-[p-dimethylaminophenyl]-7-oxahepta-2,4-dienohydroxamic Acid, HDAC Inhibitor IX, TSA
• 실험식(Hill 표기법): C₁₇H₂₂N₂O₃
• Molecular Weight: 302.37
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 저장 온도: −20°C

설명

일반 설명

A potent and reversible inhibitor of histone deacetylase. Blocks cell cycle progression at the G1 phase in HeLa cells and induces a 12-fold increase in intracellular levels of gelsolin. Induces reversion of oncogenic ras-tranformed NIH 3T3 cells to a normal morphology. Inhibits IL-2 gene expression (IC₅₀ = 73 nM) in Jurkat cells and shows immunosuppressive activity in a mouse model.

생화학적/생리학적 작용

Primary Target
histone deactylase

Target IC₅₀: 73 nM inhibiting IL-2 gene expression in Jurkat cells

경고

Toxicity: Harmful (C)

물리적 형태

A 10 mM (500 µg/165 µl) solution of Trichostatin A, Streptomyces sp. (Cat. No. 647925) in DMSO.

재구성

Following initial thaw, aliquot and freeze (-20°C).

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Flash Point (°C): 87 °C - closed cup - (Dimethylsulfoxide)