613570

TIRAP Inhibitor Peptide, Cell-Permeable

The TIRAP Inhibitor Peptide, Cell-Permeable blocks LPS-, but not CpG-induced NF-κB activation. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• 동의어(들): TIRAP Inhibitor Peptide, Cell-Permeable, Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, Ant-Tirap _138-151, TIRAP Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
• 실험식(Hill 표기법): C₁₆₃H₂₆₈N₅₂O₃₈S
• Molecular Weight: 3596.26
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 형태: lyophilized solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white
• solubility: DMSO: 5 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable synthetic peptide containing mouse TIRAP_138-151 fused to the Drosophila Antennapedia sequence. Specifically inhibits LPS-, but not CpG-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.

A synthetic, cell-permeable peptide that corresponds to mouse toll-interleukin 1 receptor (TIR) domain-containing adapter protein 138-151 (TIRAP; also called Mal (MyD88-adapter-like), fused to the Drosophila antennapedia sequence. Shown to specifically inhibit LPS-induced, but not CpG-induced, NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.κB cells at ~40 µM. Also reported to block IκBα degradation.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
LPS-induced NF-κB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kB cells

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

서열

H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Leu-Gln-Leu-Arg-Asp-Ala-Ala-Pro-Gly-Gly-Ala-Ile-Val-Ser-OH

물리적 형태

Supplied as a trifluoroacetate salt.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Toshchakov, V., et al. 2002. Nat. Immunol.3, 392.
Fitzgerald, K.A., et al. 2001. Nature413, 78.
Henneke, P. and Golenbock, D.T. 2001. Nat. Immunol.2, 828.
Horng, T., et al. 2001. Nat. Immunol.2, 835.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable