609315-M
Thyroid Hormone Receptor Antagonist, 1-850
The Thyroid Hormone Receptor Antagonist, 1-850, also referenced under CAS 251310-57-3, controls the biological activity of Thyroid Hormone Receptor. This small molecule/inhibitor is primarily used for Neuroscience applications.
동의어(들):
Thyroid Hormone Receptor Antagonist, 1-850, TR Antagonist, 1-850, 2-(2-(-(4-Nitrophenyl)-4-piperidinylidene)acetyl-N-(3-(trifluoromethyl)phenyl)-1-hydrazine Carboxamide
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C21H20F3N5O4
CAS Number:
Molecular Weight:
463.41
MDL number:
UNSPSC 코드:
12352200
추천 제품
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Quality Level
분석
≥98% (HPLC)
양식
solid
제조업체/상표
Calbiochem®
저장 조건
OK to freeze
protect from light
색상
yellow
solubility
DMSO: 5 mg/mL
저장 온도
2-8°C
일반 설명
A cell-permeable hydrazinyl-carboxamide compound that acts as a selective and high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Shown to block T3- (L-triiodothyronine) mediated interaction of TRα with NRC (nuclear receptor coactivator) and prevent the stimulation of gene expression. Exerts no effect on the retinoic acid receptor α (RARα) activity.
A cell-permeable, selective, high-affinity thyroid hormone receptor (TR) antagonist (IC50 = 1.5 µM in HeLa cells). Reported to block T3-L-triiodothyronine)-mediated interaction of TRα with nuclear receptor coactivator (NRC) and prevent stimulation of gene expression. Exhibits no antagonistic effects on retinoic acid receptor α (RARα) activity.
생화학적/생리학적 작용
Primary Target
Thyroid Hormone Receptor
Thyroid Hormone Receptor
Target IC50: 1.5 µM as antagonist for thyroid hormone receptor (TR) in HeLa cells
경고
Toxicity: Standard Handling (A)
재구성
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
기타 정보
Schapira, M., et al. 2003. Proc. Natl. Acad. Sci. USA100, 7354.
법적 정보
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
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