574661

Survivin Antagonist, S12

The Survivin Antagonist, S12 controls the biological activity of Survivin.

• 동의어(들): Survivin Antagonist, S12, Survivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one
• 실험식(Hill 표기법): C₁₇H₁₂BrNO₅
• CAS Number: 258264-62-9
• Molecular Weight: 390.18
• MDL number: MFCD00117860
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 50 mg/mL, nearly colorless
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: O=C(CC1(C(C=C(Br)C=C2)=C2NC1=O)O)C3=CC(OCO4)=C4C=C3
• InChI: 1S/C17H12BrNO5/c18-10-2-3-12-11(6-10)17(22,16(21)19-12)7-13(20)9-1-4-14-15(5-9)24-8-23-14/h1-6,22H,7-8H2,(H,19,21)
• InChI key: WFYHAKOLBICHEZ-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg).

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Berezov, A., et al. 2011. Oncogene31, 1938.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable