573130

STAT3 Inhibitor VI, S3I-201

InSolution,≥95%

• 동의어(들): InSolution STAT3 Inhibitor VI, S3I-201
• 실험식(Hill 표기법): C₁₆H₁₅NO₇S
• Molecular Weight: 365.36
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.).

A cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). The solid form of this compound (Cat. No. 573102) is also available.

포장

Packaged under inert gas

경고

Toxicity: Irritant (B)

물리적 형태

A 50 mM (5 mg/274 µl) solution of STAT3 Inhibitor VI, S3I-201 (Cat. No. 573102) in DMSO.

재구성

Following initial thaw, aliquot and freeze (-20°C).

기타 정보

Lin, L., et al. 2009. Oncogene, 28, 961.
Siddiquee, K., et al. 2007. Proc. Natl. Acad. Sci. USA104, 7391.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): 188.6 °F - closed cup - (refers to pure substance)
• Flash Point (°C): 87 °C - closed cup - (refers to pure substance)