566327

SIRT1/2 Inhibitor VII

The SIRT1/2 Inhibitor VII, also referenced under CAS 143034-06-4, controls the biological activity of SIRT1/2. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 동의어(들): SIRT1/2 Inhibitor VII, 5-(2-Naphthylidine)-2-thiobarbituric acid, SIRT1 Inhibitor V, SIRT2 Inhibitor VII
• 실험식(Hill 표기법): C₁₅H₁₀N₂O₂S
• CAS Number: 143034-06-4
• Molecular Weight: 282.32
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (NMR)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white to off-white
• solubility: DMSO: 3 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C

설명

일반 설명

A thiobarbiturate compound that acts as an inhibitor against sirtuins (IC₅₀ = 13.2 & 9.1 µM using human SIRT1 & SIRT2, respectively), the NAD⁺-dependent class III histone deacetylases (HDACs). Computer-aided molecular structural anaylsis reveals that both hydrogen bonds and van der Waals type of interactions contribute to the successful docking of the inhibitor into the nicotinamde subpocket of SIRT2 with the bulky naphthyl group being placed directly into the acetyllysine substrate channel.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Uciechowska, U., et al. 2008. ChemMedChem3, 1965.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable