551590

Quercetagetin

A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC₅₀ = 340 nM).

• 동의어(들): Quercetagetin, 3,3ʹ,4ʹ,5,6,7-Hexahydroxyflavone
• 실험식(Hill 표기법): C₁₅H₁₀O₈
• CAS Number: 90-18-6
• Molecular Weight: 318.24
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow to yellow-green
• solubility: DMSO: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C15H10O8/c16-6-2-1-5(3-7(6)17)15-14(22)13(21)10-9(23-15)4-8(18)11(19)12(10)20/h1-4,16-20,22H
• InChI key: ZVOLCUVKHLEPEV-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable flavanol compound that acts a potent, ATP-competitive, and reversible inhibitor of PIM1 kinase (IC₅₀ = 340 nM). Exhibits ≥7-fold selectivity over 8 other kinases tested, including PIM2 (IC₅₀ = 3.45 µM), and little activity toward c-Abl even at concentrations as high as 200 µM. Inhibits cellular BAD phosphorylation (IC₅₀ = 5.5 µM) and induces growth arrest (ED₅₀ = 3.8 µM) in PIM1-expressing RWPE2 cells.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
PIM1 kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 340 nM against PIM1 kinase

포장

Packaged under inert gas

경고

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Holder, S., et al. 2007. Mol. Cancer Ther.6, 163.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable