550602

PKM2 Activator II, DASA

The PKM2 Activator II, DASA modulates the biological activity of PKM2. This small molecule/inhibitor is primarily used for Biochemicals applications.

• 동의어(들): PKM2 Activator II, DASA, Pyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine
• 실험식(Hill 표기법): C₁₈H₁₈F₂N₂O₆S₂
• CAS Number: 1186654-00-1
• Molecular Weight: 460.47
• MDL number: MFCD32671972
• UNSPSC 코드: 12352200
• NACRES: NA.51

속성

• Quality Level: 100
• 분석: ≥99% (HPLC)
• 양식: powder
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: white
• solubility: DMSO: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: FC(C=CC=C1F)=C1S(N2CCN(S(C3=CC4=C(OCCO4)C=C3)(=O)=O)CC2)(=O)=O
• InChI: 1S/C18H18F2N2O6S2/c19-14-2-1-3-15(20)18(14)30(25,26)22-8-6-21(7-9-22)29(23,24)13-4-5-16-17(12-13)28-11-10-27-16/h1-5,12H,6-11H2
• InChI key: SHWNKRPMUBFWKE-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC₅₀ = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Anastasiou, D., et al. 2011. Science334, 1278.
Boxer, M.B., et al. 2010. J. Med. Chem.53, 1048.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable