5.34360

Autophagy Inhibitor VII

• 동의어(들): Autophagy Inhibitor VII, 6-Chloro-N-(1-ethylpiperidin-4-yl)-1,2,3,4-tetrahydroacridin-9-amine, Acridinamine 33, Tetrahydroacridine 33, THA33
• 실험식(Hill 표기법): C₂₀H₂₆ClN₃
• Molecular Weight: 343.89
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• 색상: white to pale yellow
• solubility: DMSO: 1.6 mg/mL; water: 50 mg/mL
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD₅₀ = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.

A cell-permeable tetrahydroacridinamine (THA) derived compound that potently suppresses autophagy (EC = 250 nM) with reduced toxicity (LD₅₀ = 27 µM) in U2OS cells. Shown to induce lysosome deacidification and increase LC3-II protein accumulation. Displays attractive biophysical properties.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.

생화학적/생리학적 작용

Cell permeable: yes

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

물리적 형태

Supplied as HCl salt.

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Wang, T., et al. 2015. J. Med. Chem.58, 3025.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable