5.33657

PI4KIIIβ Inhibitor, BF738735

• 동의어(들): PI4KIIIβ Inhibitor, BF738735, 2-Fluoro-4-(2-methyl-8-(3-(methylsulfonyl)benzylamino)imidazo[1,2-a]pyrazin-3-yl)phenol, Phosphatidylinositol-phosphate-4-Kinase III β Inhibitor, BF-738735
• 실험식(Hill 표기법): C₂₁H₁₉FN₄O₃S
• CAS Number: 1436383-95-7
• Molecular Weight: 426.46
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• Quality Level: 100
• 형태: powder
• 효능: 5.7 nM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: light gray
• solubility: DMSO: 50 mg/mL
• 저장 온도: 2-8°C

설명

일반 설명

A cell-permeable imidazo-pyrazine based compound that acts as a potent and reversible inhibitor of PI4KIIIβ (IC₅₀ = 5.7 nM). Displays excellent selectivity over PI4KIIIα (IC₅₀ = 1.7 µM) and several other lipid kinases (IC₅₀ >10 µM). Shown to dose-dependently decrease PI4P levels, reduce oxysterol-binding protein (OSBP) localization to replication organelles (ROs) and inhibit cholesterol shuttling to ROs (at 1 µM in BGM and HeLaR19 cells transfected with CVB3) at multiplicity of infection (MOI). Exhibits uniformly potent and broad spectrum antienteroviral activity across a wide range of species (EC₅₀ = 4-31 nM) and is inactive against RNA, DNA, and retroviruses.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
PI4KIII&beta

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Strating, J.R.P.M., et al. 2015. Cell Reports.10, 600.
MacLeod, A.M., et al. 2013. ACS Med. Chem. Lett.4, 585.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable