527455

PKR Inhibitor, Negative Control

The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 동의어(들): PKR Inhibitor, Negative Control, RNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
• 실험식(Hill 표기법): C₁₅H₈Cl₃NO₂
• CAS Number: 852547-30-9
• Molecular Weight: 340.59
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥95% (sum of two isomers, HPLC)
• 형태: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: yellow
• solubility: DMSO: 10 mg/mL; ethanol: 10 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• InChI: 1S/C15H8Cl3NO2/c16-8-1-2-13-9(6-8)10(15(21)19-13)3-7-4-11(17)14(20)12(18)5-7/h1-6,20H,(H,19,21)
• InChI key: ZJFMARHFPUZEKI-UHFFFAOYSA-N

설명

일반 설명

An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC₅₀ >100 µM) or in rescuing PKR-dependent translation block.

An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in the inhibition of RNA-induced PKR autophosphorylation (IC₅₀ >100 µM). Exhibits no ability to rescue the translational block imposed by human PKR.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
A negative control for PKR Inhibitor

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1