516485

Pepstatin A Methyl Ester

A cell-permeable methyl ester derivative of Pepstatin A that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase.

• 동의어(들): Pepstatin A Methyl Ester, Isovaleryl-V V-Sta-A-Sta-OCH₃, PME
• 실험식(Hill 표기법): C₃₅H₆₅N₅O₉
• Molecular Weight: 699.92
• UNSPSC 코드: 12352108
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: lyophilized
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• solubility: DMSO: 5 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516481) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (K_is = 150 nM, K_ii = 320 nM in solubilized human γ-secretase at 20°C; K_is is the inhibition constant for inhibitor binding to the free enzyme and K_ii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex). Sta = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid.

A cell-permeable methyl ester derivative of Pepstatin A (Cat. No. 516482) that acts as a potent, non-competitive, transition-state analog inhibitor of γ-secretase (K_is = 15 nM and K_ii = 32 nM in solubilized human γ-secretase; K_is is the inhibition constant for inhibitor binding to the free enzyme and K_ii is the inhibition constant for inhibitor binding to the Enzyme-Substrate complex).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
γ-secretase

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

기타 정보

Tian, G., et al. 2002. J. Biol. Chem.277, 31499.
Zhang, L., et al. 2001. Biochemistry40, 5049.
Murphy, M.P., et al. 1999. J. Biol. Chem.274, 11914.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable